Received support from the Banting Research Foundation during the early stage of his career. Went on to discover human prolactin and later created Canadian Institutes of Health Research (CIHR).
Smithies worked at the Connaught Laboratories from 1953-1960 where he developed starch gel electrophoresis, a technique used to separate genetic variants of blood plasm proteins.
Developing a process to derive insulin-producing pancreatic beta cells from stem cells to one day eliminate the need for continuous insulin injections or donor tissue transplants.
Reducing hypoglycemia for patients with type 1 diabetes, developing an artificial pancreas for the treatment of diabetes and researching cystic fibrosis related diabetes.